CYP450 y farmacogenética en Guatemala. Revisión narrativa

Rodrigo J. Vargas; Oscar Cobar

doi:10.36829/63CTS.v8i2.947

Authors

Rodrigo J. Vargas Doctorado en Ciencias Biomédicas, Escuela de Estudios de Postgrado, Facultad de Ciencias Médicas, Universidad de San Carlos,Escuela de Estudios de Postgrado, Facultad de Ciencias Médicas, Universidad de San Carlos de Guatemala
Oscar Cobar Red Latinoamericana de Implementación y Validación de pautas de farmacogenómica clínica (Relivaf-Cyted) y Universidad Galileo y Universidad del Istmo,Red Latinoamericana de Implementación y Validación de pautas de farmacogenómica clínica (Relivaf-Cyted) y Universidad Galileo y Universidad del Istmo

DOI:

https://doi.org/10.36829/63CTS.v8i2.947

Abstract

The HapMap project has generated information and queries about genetic diversity in the different populations around the world. In recent decades, research projects such as the elucidation of the genome of the Mexican Mestizo, have exposed the genetic distances between mestizos and Amerindians in Mexico. About 20 genes are currently studied in commercial panels associated with drug metabolism. One of them CY P2C19, that expresses the CY P2C19 enzyme, that metabolizes about 26 drugs of clinical importance. The objective was to review the scientific literature in Google Scholar, PubMed and ScienceDirect that reports results on pharmacogenetic studies in Guatemala, others that presented findings over genetic distances in Guatemala, as well as a comparison with the knowledge about other populations of the continent and world, with emphasis in CY P2C19 gen. Miscegenation in Guatemala was unique and is important to investigate the Guatemalan allelic variants associated with drug metabolism to allow a more effective and safe therapeutic and improve their quality of life.

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