Plasma rico en plaquetas como terapia autóloga en la medicina regenerativa: Revisión narrativa

Authors

  • Rene Aguilar Laboratorio Clinico y Banco de Sangre Aguilar
  • Armando Cáceres

DOI:

https://doi.org/10.36829/63CTS.v7i3.946

Abstract

En las últimas décadas, la terapia de plasma rico en plaquetas (PRP) ha despertado mucha atención en el área de la medicina regenerativa, siendo aplicada a diferentes patologías sistémicas y localizadas. El PRP proporciona diversos factores de crecimiento y proteínas que pueden estimular al proceso de regeneración celular, representa un factor importante para su uso clínico generalizado, en diferentes tejidos en donde el suministro de sangre es lento o limitado y apoya la recuperación, cicatrización, activación biológica de células de defensa, estabilización en la regeneración celular y tisular, teniendo uso clínico en casi todas las especialidades médicas. Esta revisión tiene como objetivo presentar las bases teóricas para la potencial aplicación del PRP y sus factores de crecimiento en tratamientos que buscan una terapia regenerativa por bioestimulación de la aplicación autóloga, en patologías para las cuales aún no existe tratamiento específico. Se revisaron artículos de los últimos 10 años en los buscadores y bases de datos Google Scholar, PubMed y Scopus y se seleccionaron aquellos que pueden ayudar a entender la aplicación de PRP en diversos procesos de regeneración, con miras a utilizarse como un tratamiento alternativo y complementario a pacientes con COVID-19. Se encontró abundante literatura experimental y clínica en el uso de PRP autóloga, en diversos procesos de regeneración, inclusive en neumología e infectología, por lo que amerita comprobar su efecto con protocolos establecidos, en patologías respiratorias severas como apoyo biológico autólogo para activar la respuesta biológica innata de tipo celular.

Downloads

Download data is not yet available.

Author Biography

Rene Aguilar, Laboratorio Clinico y Banco de Sangre Aguilar

Quetztaltenango, Regente de Laboratorio

References

Abraham, S., Rangaswamy, S. P., & Chinnaiah, A. (2019). Platelet rich plasma (PRP) therapy: An approach in endometrium regeneration. International Journal of Research and Review, 6(9), 97-102.

Aghaei, S. (2017). Platelet-rich plasma in skin rejuvenation. Journal of Surgical Dermatology, 2, 61-62. https://doi.org/10.18282/jsd.v2.i2.150

Alam, M., Hughart, R., Champlain, A., Geisler, A., Paghdal, K., Whitting, D., … Poon, E. (2018). Effect of platelet-rich plasma injection for rejuvenation of photoaged facial skin. A randomized clinical trial. JAMA Dermatology, 154(12), 1447-1452. https://doi.org/10.1001/jamadermatol.2018.3977

Alcaraz-Rubio, J., Oliver-Iguacel, A., & Sánchez-López, J. M. (2015). Plasma rico en factores de crecimiento plaquetario. Una nueva puerta a la Medicina Regenerativa. Revista de Hematología México, 16, 128-142.

Alves, R., & Grimalt, R. (2018). A review of platelet-rich plasma: History, biology, mechanism of action, and classification. Skin Appendage Disorders, 4, 18-24. https://doi.org/10.1159/000477353

Amable, P. R., Carias, R. B. V., Teixeira, M. V., Pacheco, I. C., Corrêa do Amaral, R. J. F., Granjeiro, J. M., & Borojevic, R. (2013). Platelet-rich plasma preparation for regenerative medicine: Optimization and quantification of cytokines and growth factors. Stem Cell Research & Therapy, 4(3), 67. https://doi.org/1o.1186/scrt218

Ambrosio, A. L., & Di Pietro, S. M. (2017). Storage pool disease illuminate platelet dense granules biogenesis. Platelets, 28(2), 138-146. https://doi.org/10.1080/09537104.2016.124378

Andia, I., & Maffulli, N. (2013). Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nature Reviews Rheumatology, 9(12), 721-730. https://doi.org/10.1038/nrrheum.2013.14

Anitua, E., de la Fuente, M., Muruzabal, F., Sánchez-Ávila, R. M., Merayo-Lloves, J., Azkargorta, M., … Orive, G. (2018). Differential profile of protein expression on human keratocytes treated with autologous serum and plasma rich in growth factors (PRGF). PloS One, 13(10), Article e20205073. https://doi.org/10.1371/journal.pone.0205073

Apte, S. S., Chen, D. S., & Ferrara, N. (2020). VEGF in signaling and disease: Beyond discovery and development. Cell, 176(6), 1248-1264. https://doi.org/10.1016/j.cell.2019.01.021

Assinger, A., Schrottmaier, W. C., Salzmann, M., & Rayes, J. (2019). Platelets in sepsis: An update on experimental models and clinical data. Frontiers in Immunology, 10, 1687. https://doi.org/10.3389/fimmu.2019.01687

Babaei, V., Afradi, H., Ghardani, H. Z., Nasseri, F., Azarafza, M., & Teimourian, S. (2017). Management of chronic diabetic foot ulcers using platelet-rich plasma. Journal of Wound Care, 26(12), 784-787. https://doi.org/10.12968/jowc.2017.26.12.784

Badsha, H., Harifi, G., & Murrell, W. D. (2020). Platelet rich plasma for treatment of rheumatoid arthritis: Case series and review of literature. Case Reports in Rheumatology, Article e8761485. https:/doi.org/10.1155/2020/9861485

Batlle, E., & Massagué, J. (2019). Transforming growth factor-? signaling in immunity and cancer. Immunity, 50(4), 924-940. https://doi.org/10.1016/j.immuni.2019.03.024

Bayat, M., Yazdanpanah, M. J., Alamdari, D. H., Banihashemi, M., & Salehi, M. (2019). The effect of platelet-rich plasma injection in the treatment of androgenetic alopecia. Journal of Cosmetic Dermatology, 18(6), 1624-1628. https://doi.org/10.1111/jocd.12907

Behnia-Willison, F., Nguyen, T. T. T., Norbury, A. J., Mohamadi, B., Salvatore, S., & Lam, A. (2020). Promising impact of platelet rich plasma and carbon dioxide laser for stress urinary incontinence. European Journal of Obstetrics & Gynecology and Reproductive Biology, X: 5, Article e100099. https://doi.org/10.1016/j.eurox.2019.100099

Bos-Mikich, M. A., de Oliveira., R., & Frantz, N. (2018). Platelet-rich plasma therapy and reproductive medicine. Journal of Assisted Reproduction and Genetics, 35(5), 753-756 https://doi.org/10.1007/s10815-018-1159-8

Breen, E. C. (2007). VEGF in biological control. Journal of Cellular Biochemistry, 102(6), 1358-1367. https://10.1002/jeb.21579

Cárdenas Monzón, L., & Negrin Caceres, Y. (2017). Plasma rico en plaquetas: una alternativa terapéutica versátil en enfermedades oftálmicas. Medicentro (Villa Clara), 21(2), 90-100

Castro-Piedra, S. E., & Arias-Varela, K. A. (2019). Actualización en plasma rico en plaquetas. Acta Médica Costarricense, 61(4), 142-150.

Chahla, J., Cinque, M. S., Piuzzi, N. S., Mannava, S., Geeslin, A. G., Murray, I. R., … LaPrade, R. E. (2017). A call for standardization in platelet-rich plasma preparation protocols and composition reporting A systematic review of the clinical orthopaedic literature. Journal of Bone and Joint Surgery, 99, 1769-1779. https://doi.org/10.2106/JBSJ.16.01374

Chand, J., Arora, S. A., & Chhina, S. (2020). IL-8 as a potential diagnostic salivary biomarker in periodontal diseases – A systematic review. International Journal of Science and Healthcare Research, 5(1), 55-60.

Cie?lik-Bielecka, A., Reichert, P., Skowro?ski, R., & Królikowska, A. (2019). A new aspect of in vitro antimicrobial leukocyte- and platelet-rich plasma activity based on flow cytometry assessment. Platelets, 30(6), 728-736. https://doi.org/10.1080/09537104.2018.1513472

de Araujo, R., Lôbo, M., Trinidade, K., Silvia, D. F., & Pereira, N. (2019). Fibroblast growth factors: A controlling mechanism of skin aging. Skin Pharmacology & Physiology, 32, 275-282. https://doi.org/10.1159/000501145

de Macedo, A. P., Duarte Lana, J. F. S., Pedrozo, C. M., Bottene, I. C., de Medeiros, J. R. M., & da Silva, L. Q. (2020). The regenerative medicine potential of PRP in elite athlete injuries. Fortune Journal of Rheumatology, 2, 16-26. https://10.26502/fjr.26880014

Del Fabbro, M., Bortolin, M., Taschieri, S., Ceci, C., & Weinstein, R. L. (2016). Antimicrobial properties of platelet-rich preparations. A systematic review of the current pre-clinical evidence. Platelets, 27(4), 276-285. https://doi.org/10.3109/09537104.2015.1116686

del Pino-Cedeño, T., Trujillo-Martín, M. M., Andia, I., Aragón-Sánchez, J., Herrera-Ramos., E., Iruzubieta-Barragán, F. J., & Serrano-Aguilar, P. (2018). Platelet-rich plasma for the treatment of diabetic foot ulcer. Wound Repair and Regeneration, 27(2), 170-182. https://doi.org/10.1111/wrr.12690

Dervishi, G., Liu, H., Peternel, S., Labeit, A., & Peinemann, F. (2019). Autologous platelet?rich plasma therapy for pattern hair loss: A systematic review. Journal of Cosmetic Dermatology, 19(4), 827-835. https://doi.org/10.1111/jocd.13113

Drago, L., Bortolin, M., Vassena, C., Taschieri S., & Del Fabbro, M. (2013). Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity. BMC Microbiology, 13, 47. https://doi.org/10.1186/1471-2180-13-47

Dragonas, P., Schiavo, J. H., Avila-Ortiz, G., Palaiologou, A., & Katsaros, T. (2019). Plasma rich in growth factors (PRGF) in intraoral bone grafting procedures: A systematic review, Journal of Cranio-Maxillo-Facial, 47(3), 443-453. https://doi.org/10.1016/j.jcms.2019.01.012

Epifanova, M. V., Gvasalia, B. R., Durashov, M. A., & Artemenko, S. A. (2019). Platelet-rich plasma therapy for male sexual dysfunction: Myth or reality? Sexual Medicine Reviews, 8(1), 106-113. https://doi.org/10.1017/j.sxmr.201.02.002

Everts, P. A. (2018). Autologous platelet-rich plasma and mesenchymal stem cells for the treatment of chronic wounds. En K. H. Dogan (Ed.) Wound Healing – Current Perspectives (Chapter 3), Intechopen. http://dx.doi.org/10.5772/intechopen.80502

Flori, H., Sapru, A., Quasney, M. W., Gildengorin, G., Curley, M. A. Q., Matthay, M. A., … Sepsis Investigation Network. (2019). A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome. Critical Care, 23(1), 128. https://doi.org/10.1186/s13054-019-2342-8

Franchini, M., Cruciani, M., Mengoli, C., Masiello, F., Marano, G., D’Aloja, E., ... Liumbruno, G. M. (2019). The use of platelet-rich plasma in oral surgery: A systematic review and meta-analysis. Blood Transfusion, 17(5), 357-367. https://doi.org/10.2450/2019.0177-19

Frezzetti, D., Gallo, M., Maiello, M. R., D’Alessio, A., Normanno, N., & de Luca, A. (2017), VEGF as a potential target in lung cancer. Expert Opinion on Therapeutic Targets, 21(10), 959-966. https://doi.org/10.1080/14728222.1371137

García-Salas, J. D., Carrillo-Gorena, J., Cisneros-Castolo, M. Sierra-Santiesteban, F., & Enríquez-Sánchez, L. (2018). Allogeneic activated platelet-rich plasma in skin grafts of patients with grade III burns. Cirujano General, 40(4), 230-237.

Gentile, P., & Garcovich, S. (2020). Systematic review of platelet-rich plasma use in androgenetic alopecia compared with Minoxidil®, Finasteride®, and adult stem cell-based therapy. International Journal of Molecular Sciences, 21(8), 2702. https://doi.org/10.3390/ijms21082702

Ghai, B., Gupta, V, Jain, A., Goel, N., Chouhan, D., & Batra, Y. K. (2019). Effectiveness of platelet rich plasma in pain management of osteoarthritis knee: Double blind, randomized comparative study. Revista Brasileira de Anestesiologia, 69(5), 439-447. https://doi.org/10.1016/j.bjane.2019.06.005

Giannoni, P., Fais, F., Cutrona, G., & de Totero, D. (2019). Hepatocyte growth factor: A microenvironmental resource for leukemic cell growth. International Journal of Molecular Sciences, 20(2), 292. https://doi.org/10.3390/ijms200020292

Glavina, A., Vucicevic Boras, V., Gabric, D., Susic, M., Granic, M., & Pelivan, I. (2017). Plasma rich in growth factors in dentistry. Australasian Medical Journal, 10(6), 497–501. https://doi.org/10.21767/AMJ.2017.3000

Glynn, L. G., Mustafa, A., Casey, M., Krawczyk, J., Blom, J., Galvin, R., … Mallen, C. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: A feasibility study in primary care Pilot and Feasibility Studies, 4(93). https://doi.org/10.1186/s40814-018-0288-2

Gökçe Kütük, S., & Özda?, T. (2018). The impact of platelet-rich plasma therapy on short-term postoperative outcomes of pediatric tonsillectomy patients. European Archives of Oto-Rhino-Laryngology, 276(2), 48-495. https://doi.org/10.1007/s00405-018-5211-1

Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., ... Sette, A. (2020). Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell, 181(7), 1489-1501. https://doi.org/10.1016/j.cell.2020.05.015

Groeneveldt, C., van Hall, T., van der Burg, S. H., ten Dijke, P., & van Montfoort, N. (2020). Immunotherapeutic potential of TGF-? inhibition and oncolytic virus. Trends in Immunology, 41(5), 406-420. Httos://doi.org/10-1016/j.it.2020.03.003

Gupta, A. K., & Carviel, J. L. (2017). Meta-analysis of efficacy of platelet-rich plasma therapy for androgenetic alopecia. Journal of Dermatological Treatment, 28(1), 55-58. https://doi.org/ 10.1080/09546634.2016.1179712

Hasan, I., & Kumar, P. (2020). Platelet rich plasma (P.R.P.) treatment: A view. International Journal of Clinical Nursing, 1(1), 34-47

Hassanien, M., Elawamy, A., Kamel, E. Z., Khalifa, W. A., Makarem, Y. S., Abolfadl, G. M., … El Zohne, R. A. (2019). Perineural platelet-rich plasma for diabetic neuropathic pain, could it make a difference? Pain Medicine, 21(4), 757-765. https://doi.org/10.1093/pm/pnz140

He, M., Guo, X., Li, T., Jiang, X., Chen, Y., Yuan, Y., … Deng, W. (2020). Comparison of allogenic platelet-rich plasma with autologous platelet-rich plasma for the treatment of diabetic lower extremity ulcer. Cell Transplantation, 29, 1-9. https://doi.org/10.1177/096368970931428

Hersant, B., Sid-Ahmed, M., Braud, L., Jourdan, M., Baba-Amer, Y., Meningaud, J.-P., & Rodriguez, A.-M. (2019). Platelet-rich plasma improves de wound healing potential of mesenchymal stem cells through paracrine and metabolism alterations. Stem Cell International, Article e1234263. https://doi.org/10.1155/2019/1234263

Hirayama, K., Su, Y., Chiba, M., Iztusu, M., & Yuki, M. (2020). Relationship between quality of life and skin toxicities of epidermal growth factor receptor inhibitor in cancer patients: A literature review. Japan Journal of Nursing Science, 17(3), Article e12321. https://doi.org/10.1111/jjns.12321

Hu, Z., Qu, S., Zhang, J., Cao, X., Wang, P., Huang, S., … Zhu, J. (2019). Efficacy and safety of platelet-rich plasma for patients with diabetic ulcers: A systematic review and meta-analysis. Advances in Wound Care, 8, 298-308. https://doi.org/10.1089/wound.2018.0842

Kardas, G., Daszy?ska-Kardas, A., Marynowski, M., Brz?kaska, O., Kuna, P., & Panek, M. (2020). Role of platelet-derived growth factor (PDGF) in asthma as an immunoregulatory factor mediating airway remodeling and possible pharmacological target. Frontiers in Pharmacology, 11, 47. https://doi.org/10.3389/fphar.2020.00047

Kitamura, K., Nagoshi, N., Tsuji, O., Matsumoto, M., Okano, H., & Nakamura, M. (2019). Application of hepatocyte growth factor for acute spinal cord injury: The road from basic studies to human treatment. International Journal of Molecular Sciences, 20(5), Article e1054. https://doi.org/10.3390/ijms20051054

Koupenova, M., Corkrey, H. A., Vitseva, O., Manni, G., Pang, C. J., Clancy, L., … Freedman, J. E. (2019). The role of platelets in mediating a response to human influenza infection. Nature Communications, 10(1), Article e1780. https://doi.org/10.1038/s41467-019-09607-x

Li, H., & Li, B. (2013). PRP as a new approach to prevent infection: Preparation and in vitro antimicrobial properties of PRP. Journal of Visualized Experiments, (74), Article e50351. https://doi.org/10.3791/50351

Li, T., Ma, Y., Wang, M., Wang, T., Wei, J., Ren, R., … Chen, B. (2019). Platelet-rich plasma plays an antibacterial, anti?inflammatory and cell proliferation?promoting role in an in vitro model for diabetic infected wounds. Infection and Drug Resistance, 12, 297-309. https://doi.org/10.2147/IDR.S186651

Li, Z. J., Choi, H.-I., Choi, D.-K., Sohn, K.-C., Im, M., Seo, Y.-J., … Lee, Y. (2012). Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Dermatologic Surgery,38(7 Pt 1), 1040-1046. https://doi.org/10.1111/j.1524-4725.2012.02394.x

Maher, Z. M., Elsayied, A. R.A., & El.Din, M. M. M. (2020). Clinicopathological studies on the remodeling effect of platelet-rich plasma on lung fibrosis induced by amiodarone in albino mice. Veterinary Medicine & Public Health Journal, 1(3), 108-114. https://doi.org/10.31559/vmph2020.1.3.8

Mammoto, T., Chen, Z., Jiang, A., Jiang, E., Ingber, D. E., & Mammoto, A. (2015a). Acceleration of lung regeneration by platelet-rich plasma extract through the low-density lipoprotein receptor-related protein 5-Tie2 pathway. American Journal of Respiratory Cell and Molecular Biology, 54(1), 103-113. https://doi.org/10.1165/rcmb.2014.0045OC

Mammoto, T., Jiang, A., Jiang, E., & Mammoto, A. (2015b). Platelet-rich plasma extract pulmonary edema through angiopoietin-Tie2 signaling. American Journal of Respiratory Cell and Molecular Biology, 52(1), 56-64. https://doi.org/10.1165/rcmb.2014-007OC

Marck, R. E., Gardien, K. L. M., Vlig, M., Breederveld, R. S., & Middelkoop, E. (2019). Growth factor quantification of platelet-rich plasma in burn patients compared to matched healthy volunteers. International Journal of Molecular Sciences, 20(2), 288. https//doi.org/10.3390/ijms20020288

Martínez, C. E., Gómez, R., Kalergis, A. M., &. Smith, P. C. (2018). Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations. Clinical Oral Investigation, 23(5), 2455-2463. hppts://doi.org/10.1007/s00784-018-2637-1

Mercuri, S. R., Vollono, L., & Paolino, G. (2020). The usefulness of platelet-rich plasma (PRP) for the treatment of vitiligo: State of the art and review. Drug Design, Development and Therapy, 14, 1749-1755. hptts://doi.org/10.2147/DDDT.S239912

Medvedev, VL, Kogan, MI, Mihailov, IV y Lepetunov, SN (2020). Plasma autólogo rico en plaquetas: ¿que es y para que ?. Urology Herald , 8 (2), 67-77. https://doi.org/10.21886/2308-6424-2020-8-2-67-77

Miron, R. J., & Choukroun, J. (Ed.). (2017). Platelet rich fibrin in regenerative dentistry. Biological background and clinical indications. Oxford, UK: Wiley Blackwell.

Montiel Saura, Y., Chamizo Cabrera, M. G., & Arce González, M. (2017). Plasma rico en plaquetas y uso terapeútico en vitíligo. Folia Dermatológica Cubana, 11(3), Article e63,

Nicolai, L., Gaertner, F., & Massberg, S. (2019). Platelets in host defense: Experimental and clinical insights. Trends in Immunology, 40(10), 922-938. https://doi.org/10.1016/j.it.2019.08.004

Nunes, Q. M., Li, Y., Sun, C., Kinnunen, T. K., & Ferning, D. G. (2016). Fibroblast growth factors as tissue repair and regeneration therapeutics. PeerJ, 4, Article e1535. https://doi.org/10.7717/peerj.1535

Ozcan, P., Takmaz, T., Tok, O. E., Islek, S., Yigit, E. N., & Ficicioglu, C. (2020). The protective effect of platelet-rich plasm administered on ovarian function of female rats with Cy-induced ovarian damage. Journal of Assisted Reproduction and Genetics, 37(3), 865-873. https://doi.org/10.1007/s10815-020-01689-7

Pardo, M., Cheng, Y., Stibon, Y. H, Lowell, J. A., Grieco, S. F., Worthen, R. J., … Barrera-Diaz, A. (2018). Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review. Neuroscience Research, 149, 1-13. https://doi.org/j.neures.2018.10.012

Patel, A. N., Selzman, C. H., Kumpati, G. S., McKellar, S. H., & Bull, D. A. (2016). Evaluation of autologous platelet rich plasma for cardiac surgery: Outcome analysis of 2000 patients. Journal of Cardiothoracic Surgery, 11, Article 62. https://doi.org(10.1186/s13019-016-0542-9

Pavlovic, V., Ciric, M., Jovanovic, V., & Stojanovic, P. (2016). Platelet rich plasma: a short overview of certain bioactive components. Open Medicine, 11(1), 242-247. https://doi.org/10.1515/med-2016-0048

Piccin, A., Di Pierro, A. M., Canzian, L., Primerano, M., Corvetta, D., Negri, G., … Fontanella, F. (2017). Platelet gel: A new therapeutic tool with great potential. Blood Transfusion, 15(4), 333-340. https://doi.org/10.2450/2016.0038-16

Planas Pavón, M., González Piedra, M., Zamora Santiesteban, Y., & Fuentes Céspedes, O. (2019). Aplicación del plasma rico en plaquetas en la especialidad de cirugía plástica y caumología. Investigación Medicoquirúrgicas, 11 (Supl. 1).

Presta, M., Chiodelli, P., Giacomani, A., Rusnati, M., & Ronca, R. (2017). Fibroblast growth factors 8FGFs) in cancer: FGF traps as a new therapeutic approach. Pharmacology & Therapeutics, 179, 171-187. https://doi.org/10.1016/j.pharmthera.2017.05.013

Raeissadat, S. A., Babae, M., Rayegani, S. M., Hashemi, Z., Hamidieh, A. A., Mojgani, P., & Vanda, H. F. (2017). An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies. Future Science OA, 3(4), FSO231. https://doi.org/10.4155/fsoa-2017-0045

Rashid, H., & Kwoh, C. K. (2019). Should platelet-rich plasma or stem cell therapy be used to treat osteoarthritis? Rheumatic Disease Clinics of North America, 45(3), 417-438. https://doi.org/10.1016/j.rdc.2019.04.010

Rauniyar, K., Jha, S. K., & Jeltsch, M. (2018). Biology of vascular endothelial growth factor C in the morphogenesis of lymphatic vessels. Frontiers in Bioengineering and Biothechnology, 6, 7. https://doi.org/10.3389)fbioe.2018.00007

Redler, L. H., Thompson, S. A., Hsu, S. H., Ahmad, C. S., & Levine, W. N. (2011). Platelet-rich plasma therapy: A systematic literature review and evidence for clinical use. Physician and Sportsmedicine, 39(1), 42-51. https://doi.org/10.3810/psm.2011.02.1861

Rioseco, P., Céspedes, V., Muñoz, S., Tapia, S., & Vásquez, D. (2014). Utilidad del plasma rico

en plaquetas en neumología. Revista Chilena de Enfermedades Respiratorias, 30(3), 156-165. http://dx.doi.org/10.4067/S0717-73482014000300005

Rioseco, S. P., Tapia, Z. S., Céspedes, S. V., Silva, J. P., & Lozano, F. P. (2020). Reporting the usage of platelet rich plasma (PRP) in the treatment of acute post intubation tracheal rupture in two cases. Current Topics in Medicine and Medical Research, 4, 130-140.

Rodríguez Flores, J., Palomar Gallego, M. A., & García-Denche, J. T. (2012). Plasma rico en plaquetas: fundamentos biológicos y aplicaciones en cirugía maxilofacial y estética facial, Revista Española de Cirugía Oral y Maxilofacial, 34(1), 8-17. https://doi.org/10.1016/j.maxilo.2011.10.007

Salama, S. M., Kamel, I. H., Ghanem, M., & El-Sherif, A. F. (2019). The efficacy of autologous nebulized platelet rich plasma (PRP) as an early adjuvant therapeutic and prognostic treatment modality in the management of inhalation lung injury. Egyptian Journal of Plastic Reconstruction Surgery, 43(2), 203-208. https://doi.org/10.21608/EJPRS.2019.65115

Salem, N., Helmi, N., & Assaf, N. (2018). Renoprotective effect of platelet-rich plasma on cisplatin-induced nephrotoxicity in rats. Oxidative Medicine and Cellular Longevity, Article e9658230. https://doi.org/10.1155/2018/9658230

Samadi, P., Sheykhhasan, M., & Khoshinani, H. M. (2018). The use of platelet-rich plasma in aesthetic and regenerative medicine: A comprehensive review. Aesthetic Plastic Surgery, 43(3), 803-814. https://doi.org/10.1007/s00266-018-1293-9

Santos, S. C., Sigurjonsson, O. E., Custódio, C. A., & Mano, J. F. (2018). Blood plasma derivatives for tissue engineering and regenerative medicine therapies. Tissue Engineering. Part B, Reviews, 24(6), 454-462. https://doi.org/10.1089/ten.TEB.2018.0008

Scott, S., Roberts, M., & Chung., E. (2019). Platelet-rich plasma and treatment of erectile dysfunction: Critical review of literature and global trends in platelet-rich plasma clinics. Sexual Medicine Reviews, 7(2), 306-312. https://doi.org/10.1016/j.sxmr.2018.12.006

Sharda, A., & Flaumenhaft, R. (2018). The life cycle of platelet granules. F1000Research, 7, 236. https://doi.org/f1000research.13283.1

Shareef, S. A., Abdulla, J. E., Shakor, J. K., & Qadir, O. H. (2020). Stimulating and boosting the immune system by increasing the number of white blood cells (leukocytes) to prevent and treat some viral infections. Prensa Médica Argentina, 106(5), 236.

Shen, T., You, Y., Joseph, C., Mirzaei, M., Klistoner, A., Graham, S. L., & Gupta, V. (2017). BNDF polymorphism: A review of its diagnostic and clinical relevance in neurodegenerative disorders. Aging and Disease, 9(3), 523-536. https://doi.org/10.14336/AD.2017.0717

Shi, G.-J., Shi, D.-R., Zhou, J.-Y., Zhang, W.-J., Gao, C.-Y., Jiang, Y.-P., … Yu, J.-Q. (2018). Involvement of growth factors in diabetes mellitus and its complications: A general review. Biomedicine & Pharmacotherapy, 101, 510-527. https://doi.org/10.1016/j.biopha.2018.02.105

Singh, A., Gill, G. K., & Malhotra, N. (2019). Efficacy of autologous platelet rich plasma (prp) dressing in diabetic foot ulcer: An observational study. International Journal of Orthopaedics Sciences, 5(3), 53-543

Solakoglu, O., Heydecke, G., Amiri, N., & Anitua, E. (2020). The use of plasma rich in growths factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans. Annals of Anatomy – Anatomischer Anzeiger, 231, Article 151528. https://doi.org/10.1016/j.aanat.2020.151528

Sommeling, C. A., Heyneman, A., Hoeksema, H., Verbelen, J., Stillaert, F. B., & Monstrey, S. (2013). The use of platelet-rich plasma in plastic surgery: A systematic review. Journal of Plastic, Reconstructive & Aesthetic Surgery, 66(3), 301-312. https://doi.org/10.1016/j.bjps.2012.11.009

Sriram, S., Sankaralingam, R., Mani, M., & Tamilselvam, T. N. (2016). Autologous platelet rich plasma in the management of non-healing vasculitic ulcers. International Journal of Rheumatic Diseases, 19(12), 1331–1336. https://doi.org/10.1111/1756-185X.12914

Tabrizi, A., Dindarian, S., & Mohammadi, S. (2020). The effect t of corticosteroid local injection versus platelet-rich-plasma for the treatment of plantar fasciitis in obese: A single-blind randomized clinical trial. Journal of Foot & Ankle Surgery, 59(1), 64-68. https://doi.org/10.1053/j.jfas.2019.07.004

Tiwari, M., & Bhargava, R. (2013). Platelet rich plasma therapy: A comparative effective therapy with promising results in plantar fasciitis. Journal of Clinical Orthopaedics and Trauma, 4(1), 31-35. https://doi.org/10.1016/j.jcot.2013.01.008

Tong, J., Cao, L., Liu, L., & Jin, M. (2020). Impact of autologous platelet rich plasma use on postoperative acute kidney injury in type A acute aortic dissection repair: A retrospective cohort analysis. Research Square. https://doi.org/10.21203/rs.3.rs-66758/v1

Tripathi, V. K., & Gupta, P. (2018). Management of diabetic foot ulcers with platelet rich plasma: A clinical study. National Journal of Clinical Orthopaedics, 2(3), 9-11.

Trull-Ahuir, C., Sla, D., Chismol-Abad, J., Vila-Caballer, M., & Lisón, J. F. (2020). Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial. Scientific Reports, 10, Article 2085. https://doi.org/10.1038/s41598-020-59113-0

Tsujino, T., Isobe, K., Kawabata, H., Aizawa, H., Yamaguchi, S., Kitamura, Y., … Kawase, T. (2019). Spectrophotometric determination of the aggregation activity of platelets in platelet-rich plasma for better quality controls. Dentistry Journal, 7(2), Article 61. https://doi.org/10.3390/dj7020061

Valadez Báez, X. L., Hernández Santos, J. R., Torres Huerta, J. C., Tenopala Villegas, S., & Canseco Aguilar, C. P. (2016). Método óptimo para la obtención de plasma rico en plaquetas en el Servicio de Clínica del Dolor del CMN 20 de noviembre ISSSTE. Revista de la Sociedad Española del Dolor, 23(4), 175-180. https://doi.org/10.20986/resed.2016.3419/2016

Varshney, S., Dwivedi, A., & Pandey, V. (2019). Antimicrobial effect of various platelet rich concentrates-vibes from in-vitro studies – A systematic review. Journal of Oral Biology and Craniofacial Research, 9(4), 299-305. https://doi.org/10.1016/j.joncr.2019.06.013

Wang, M., Wei, J., Shang, F., Zang, K., & Ji, T. (2019). Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory response. International Immunopharmacology, 75, Article 10572. https:/doi.org/10.1016/j.intimp.2019.105792

Werner, B. C., Cancienne, J. M., Browning, R., Verma, N. N, & Cole, B. J. (2020). An analysis of current treatment trends in platelet-rich plasma therapy in the Medicare Database. Orthopaedic Journal of Sports Medicine, 8(2). https://doi.org/10.1177/2325967119900811

Wesner, M., Defreitas, T., Bredy, H., Pothier, L., Qin, Z., McKillop, A. B., & Gross, D. P. (2016). A pilot study evaluating the effectiveness of platelet-rich plasma therapy for treating degenerative tendinopathies: A randomized control trial with synchronous observational cohort. PLoS One, 11(2), Article e0147842. https://doi.org/10.1371/journal.pone.0147842

Wróbel-Dudzi?ska, D., Alio, J., Rodriguez, A., Suchodola-Ratejewicz, E., Kosior-Jarecka, E., Rymgayllo-Jankowska, B. … ?arnowski, T. (2018). Clinical efficacy of platelet-rich-plasma in the treatment of neurotrophic corneal ulcer. Journal of Ophthalmology, Article 3538768. https://doi.org/10.1155/2018/3538764

Wu, H. E., Teixeira, A. L., Barroso, L., Silva, A. P. M., Nicolau, M. S., Ferreira, J. D. R., …. Diniz, B. S. (2019). Epidermal growth factor and fibroblast growth factor-2 circulating levels in elderly with major depressive disorders. Psychiatric Research, 272, 141-143. https://doi.org/10.1017/j.psychres.2018.12.084

Xu, J., Gou, L., Zhang, P., Li, H., & Qiu, S. (2020). Platelet-rich plasma and regenerative dentistry, Australian Dental Journal, 2020. https://doi.org/10.1111/adj.12754

Yadav, S., & Storrie, B. (2017). The cellular basis of platelet secretion: Emerging structure/ function relationship. Platelets, 28(2), 108-118. https://doi.org/10.1080/09537104.2016.1257786

Yaradilmis, Y. U., Demirkele, I., Tagral, A. S., Okkaoglu, M. C., Ates, A., & Altay, M. (2020). Comparison of two platelet rich plasma formulations with viscosupplementation in treatment of moderate grade gonarthrosis: A prospective randomized controlled study. Journal Orthopedics, Clinical, 28, 240-246. https://doi.org/10.1016/j.jor.2020.01.041

Ylä-Herttula, S., Rissanen, T. T., Vajanto, I., & Hartikainen, J. (2007). Vascular endothelial growth factors. Journal of American College of Cardiology, 49(10), 1015-1026. https://doi.org/10.1016/j.jacc.2006.09.053

Zarin, M., Karbalaei, N., Keshtgar, S., & Nemati, M. (2020). Platelet-rich plasma improves impaired glucose hemostasis, disrupted insulin secretion, and pancreatic oxidative stress in streptozotocin-induced diabetic rat. Growth Factors, 37, 226-237. https://doi.org/10.1080/0897714.2020.1735382

Zhang, W., Guo, Y., Kuss, M., Shi, W., Aldrich, A. L., Untrauer, J., … Duan, B. (2019). Platelet-rich plasma for the treatment of tissue infection: Preparation and clinical evaluation. Tissue Engineering Part B, 25(3), 225-236. https://doi.org/10.1089/ten.teb.2018.0309

Zhou, Y., Shen, H., Wu, Y., Zhao, X., Pei, J., Mou, Z., ... Hua, C. (2020). Platelet-rich plasma therapy enhances the beneficial effect of bone marrow stem cell transplant on endometrial regeneration. Frontiers in Cell and Developmental Biology, 8, 52. https://doi.org/10.3389/fcell.2020.00052

Zou, G., Zheng, M., Chen, W., He, X., & Cang, D. (2020). Autologous platelet-rich plasma therapy for refractory pain after low-grade medial collateral ligament injury. Journal of International Medical Research, 48(2), 1-7. https://doi.org/10.1177/0300060520903636

Published

2020-11-26

How to Cite

Aguilar, R., & Cáceres, A. (2020). Plasma rico en plaquetas como terapia autóloga en la medicina regenerativa: Revisión narrativa. Ciencia, Tecnología Y Salud, 7(3), 442–460. https://doi.org/10.36829/63CTS.v7i3.946

Issue

Section

Artículos de revisión

Most read articles by the same author(s)

1 2 > >>