Ameliorative effects of Tagetes lucida on gentamicin-induced nephrotoxicity, diabetic nephropathy and heat exposure in animal models
DOI:
https://doi.org/10.36829/63CTS.v10i2.1385Keywords:
Aminoglycosides; hyperglycemia; dehydration, kidney, in vivoAbstract
There are multiple noxious factors for the kidney that have a considerable impact on public health, such as hypertension, diabetes, exposure to nephrotoxic drugs, polluting environmental factors such as heavy metals or pesticides, and chronic dehydration, among others. Several species are traditionally used for the treatment of conditions associated with the kidney, with an important relationship with the blood purification system, substance excretion, and renal protection. However, the nephroprotective activity of species traditionally reported in Guatemala for kidney disorders has not been explored to date. This study aimed to evaluate the in vivo protective effects of an ethanolic extract of Tagetes lucida Cav. against gentamicin-induced nephrotoxicity, streptozotocin-induced diabetic nephropathy, and dehydration produced by heat exposure. Nephrotoxicity was induced in male rats by the administration of intraperitoneal gentamicin (IP, 100 mg/kg) for 8 days; diabetes was induced by streptozotocin (110 mg/kg IP) with evaluation of diabetic progression for 3 months; and dehydration was produced by continuous heat exposure of 1.5 hours at 37° C for 5 weeks, assessing body weight, blood glucose, creatinine, urea and protein in blood and urine. Oral administration of 100 mg/Kg of T. lucida significantly attenuated (P ˂ 0.05) the elevation of creatinine and urea levels in rats exposed to gentamicin and in diabetic nephropathy in mice. Finally, the T. lucida extract significantly suppressed the elevation of urea levels in urine compared to the water-deprived heat-dehydrated control group. These data suggest that T. lucida has potential nephroprotective and metabolic effects that could be beneficial in preventing kidney damage.
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